Combination of Metal ‐Phenolic Network‐Based Immunoactive Nanoparticles and Bipolar Irreversible Electroporation for Effective Cancer Immunotherapy

For successful cancer immunotherapy, the authors present a combination therapy of metal-phenolic network-based nanoparticles and bipolar irreversible electroporation (IRE). Antigen-presenting cells are primed by a CpG-ODN-coated Mn-phenolic network (CMP) that elicits M1 polarization and proinflammatory cytokine release. Immunogenic cell death is induced by the bipolar IRE. Finally, the combination of CMP nanoparticles with bipolar IRE demonstrates superior anti-tumor activity. AbstractTo circumvent the limitations of conventional cancer immunotherapy, it is critical to prime antigen-presenting cells (APCs) to initiate the cancer-immune cycle. Here, the authors develop a metal-phenolic network (MPN)-based immunoactive nanoparticle in combination with irreversible electroporation (IRE) for an effective cancer immunotherapy. The MPN nanoparticles are synthesized by coordinating tannic acid with manganese (Mn) ions, and subsequent coating with CpG-oligodeoxynucleotides (CpG-ODNs) via hydrogen bonding. The CpG-ODN-coated Mn-phenolic network (CMP) nanoparticles are effectively internalized into macrophages, a type of APCs, and successfully trigger M1 polarization to promote release of proinflammatory cytokines. Notably, the CMP nanoparticles demonstrate an extended retention time period than the free CpG-ODN in the tumor. The tumor microenvironment tailored bipolar IRE, enhances the therapeutic efficacy by significantly broadening the ablation zone, which further increases immunoge...
Source: Small - Category: Nanotechnology Authors: Tags: Research Article Source Type: research