pH Stimuli ‐Responsive, Rapidly Self‐healable Coatings Enhanced the Corrosion Resistance and Osteogenic Differentiation of Mg‐1Ca Osteoimplant

A pH stimuli-responsive silk-halloysite (HNT)/phytic acid (PA) self-healing coating (Silk-HNT/PA) is fabricated on Mg-1Ca alloy. Halloysite (HNT) significantly improves the loading efficiency and shortens the self-healing time of Silk-PA coating. The Silk-HNT/PA coating improves the corrosion resistance and osteogenic differentiation of Mg-1Ca alloy. AbstractMg-Ca alloys have emerged as a promising research direction for biomedical implants in the orthopedic field. However, their clinical use is deterred by their fast corrosion rate. In this work, a pH stimuli-responsive silk-halloysite (HNT)/phytic acid (PA) self-healing coating (Silk-HNT/PA) is constructed to slow down the corrosion rate of Mg-1Ca alloy and its cell viability and osteogenic differentiation ability are enhanced. The Silk-HNT/PA coating exhibits appealing active corrosion protection, by eliciting pH-triggerable self-healing effects, while simultaneously affording superior biocompatibility and osteogenic differentiation ability. Moreover, in vivo studies by histological analysis also demonstrate better osseointegration for the Silk-HNT/PA coated Mg-1Ca alloy. In summary, the Silk-HNT/PA coating in the present study has great potential in enhancing the biomedical utility of Mg alloys.
Source: Small - Category: Nanotechnology Authors: Tags: Research Article Source Type: research