Mechanisms and Interventions on Acute Lower Limb Ischemia/Reperfusion Injury: A Review and Insights from Cell to Clinical Investigations

This review aims to highlight mechanistic insights on skeletal muscle ischemia/reperfusion injury (IRI), a potentially life-threatening complication after acute lower limb ischemia. Lower limb IRI produces a wide spectrum of manifestations, ranging from local skeletal muscle necrosis to multi-organ failure. There is increasing evidence from both in vitro and in vivo reports to demonstrate several promising interventions that have successfully reduced IRI in skeletal muscle ischemic models. However, clinical studies to confirm their benefits are still lacking.

Source: Annals of Vascular Surgery - May 15, 2022 Category: Surgery Authors: Poon Apichartpiyakul, Krekwit Shinlapawittayatorn, Kittipan Rerkasem, Siriporn C. Chattipakorn, Nipon Chattipakorn Tags: General Review Source Type: research