Association between stool consistency and clinical variables among infants with cystic fibrosis: Findings from the BONUS study

Gastrointestinal (GI) symptoms in infants with cystic fibrosis (CF) are common and frequently occur prior to the onset of respiratory symptoms [1]. CF transmembrane conductance regulator (CFTR) is present throughout the GI tract with important functions in regulating luminal viscosity, inflammation, gut flora, motility and pH [2 –4]. As such, mutated CFTR can present early in life with a wide variety of clinical symptoms including, but not limited to, meconium ileus, constipation, loose stools, steatorrhea and poor nutrition.

Source: Journal of Cystic Fibrosis - May 15, 2022 Category: Respiratory Medicine Authors: A. Jay Freeman, Rong Huang, Sonya L. Heltshe, Daniel Gelfond, Daniel H. Leung, Bonnie R. Ramsey, Drucy Borowitz, Meghana Sathe, BONUS Study Investigators Source Type: research