Perioperative pharmacological interventions for fetal immobilisation during fetal surgery and invasive procedures

CONCLUSIONS: We were only able to include one study with a small number of women, from a single centre, a European tertiary hospital. This study was published in 2005 with an abstract of this trial published in 2004. This study evaluated two intravenous medications administered to the mother - remifentanil and diazepam. This study reported our prespecified primary outcome but only evaluated several of our secondary outcomes, which limited further assessment. Low-certainty evidence suggested that remifentanil may be better at reducing fetal movements and surgeons were more satisfied with the procedure. However, maternal sedation and depression of breathing may be worse with remifentanil. Further high-quality RCTs assessing both fetal and maternal medications are required to evaluate their efficacy for fetal immobilisation as well as safety for both mother and fetus.PMID:35553414 | PMC:PMC9099215 | DOI:10.1002/14651858.CD011068.pub2
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Source Type: research