Extracellular vesicles from blood of breast cancer women induce angiogenic processes in HUVECs

In this study we studied whether EV fractions deprived of platelet EVs from breast cancer women (BC EVs) can mediate cell processes related with angiogenesis in human umbilical vein endothelial cells (HUVECs). Our findings demonstrate that BC EVs enhance migration, invasion and formation of new tubules in HUVECs, compared with EV fractions deprived of platelet EVs from healthy women (Ctrl EVs). In summary, we demonstrate, for the first time, that BC EVs induce cellular processes in HUVECs that participate in angiogenesis.PMID:35526310 | DOI:10.1016/j.tice.2022.101814
Source: Tissue and Cell - Category: Cytology Authors: Source Type: research