The NOP antagonist BTRX-246040 increases stress resilience in mice without affecting adult neurogenesis in the hippocampus

This study, performed with a clinically viable ligand, further corroborates growing evidence indicating that the blockade of the NOP signaling may provide an innovative strategy for the treatment of stress related psychopathologies.PMID:35513173 | DOI:10.1016/j.neuropharm.2022.109077

Source: Neuropharmacology - May 5, 2022 Category: Drugs & Pharmacology Authors: Flora D'Oliveira da Silva Joaquim Azevedo Neto Chiara Sturaro Annunziata Guarino Cathaline Robert Elaine C Gavioli Girolamo Calo Lionel Mouledous Chiara Ruzza Source Type: research