Emerging microtubule Targets in glioma therapy

Major advances in the genomics and epigenomics of diffuse gliomas and glioblastoma have not been translated to date into effective therapy, necessitating pursuit of alternative treatment approaches for these therapeutically challenging tumors. Current knowledge of microtubules in cancer and the development of new microtubule-based treatment strategies for high-grade gliomas are the topic in this review article. Discussed are cellular, molecular, and pharmacological aspects of the microtubule cytoskeleton underlying mitosis and interactions with other cellular partners involved in cell cycle progression, directional cell migration and tumor invasion.
Source: Seminars in Pediatric Neurology - Category: Neurology Authors: Source Type: research