The impact of nebulized Epoprostenol and Iloprost on hemoglobin oxygen affinity - an ex-vivo experiment

Conclusion Prostacyclin-receptor stimulation and subsequent cAMP mediated ATP release from erythrocytes might explain the effect of epoprostenol on Hb-O2 affinity but the reason for the sex hormone modified iloprost effect remains unclear. This finding is of great interest, as contraception is recommended for women taking iloprost. Being aware of potentially differing effects on Hb-O2 affinity might help select the right prostacyclin (epoprostenol vs. iloprost) depending on the patient and the underlying disease (e.g., acute respiratory distress syndrome vs. peripheral arterial disease).PMID:35503651 | DOI:10.1152/ajplung.00084.2022
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - Category: Cytology Authors: Source Type: research