Midbrain cholinergic neurons signal negative feedback to promote behavioral flexibility

Trends Neurosci. 2022 May 6:S0166-2236(22)00079-0. doi: 10.1016/j.tins.2022.04.005. Online ahead of print.ABSTRACTCholinergic neurons of the pedunculopontine nucleus (PPN) are relevant for adaptive behavior. In a recent study, Ruan et al. revealed that PPN cholinergic neurons signal negative feedback during reward omission after contingency changes, which is necessary for switching to new behavioral strategies.PMID:35534340 | DOI:10.1016/j.tins.2022.04.005

Source: Trends in Neurosciences - May 9, 2022 Category: Neuroscience Authors: Nadine K Gut Juan Mena-Segovia Source Type: research