Macular Morphologic and Microvascular Analysis in Pseudophakic Children with Previous Pediatric Cataract Using Optical Coherence Tomography Angiography

Introduction: The macular morphologic and microvascular changes in children with pseudophakia after pediatric cataract surgery remains unknown. The aim of this study was to analyze macular morphologic and microvascular remodeling in children with pseudophakia after pediatric cataract surgery using optical coherence tomography angiography (OCTA). Methods: Consecutive cases between December 1, 2018, and November 31, 2020 were recruited. Sixty-one participants (31 pseudophakic children and 30 healthy controls) met the inclusion criteria and were included for final analysis. OCTA was used to measure macular vascular density, the foveal avascular zone (FAZ) and macular thickness. The parameters were compared between pseudophakic and healthy eyes using binary logistic regression, with adjustment for the effect of refractive error, age and axial length. Results: Compared with the normal eyes, a significantly reduced area of the FAZ (P = .042), increased superficial foveal vascular density (P = .033), and increased inner and outer foveal thickness (P = .034 and .029, respectively) were noted in pseudophakic eyes. The deep parafoveal vascular density was generally lower in eyes with cataracts (P ≤ .044). The inner foveal thickness was positively correlated with the superficial foveal vascular density (r = .889, P
Source: Ophthalmic Research - Category: Opthalmology Source Type: research