Mycobacterium tuberculosis effectors interfering host apoptosis signaling

Abstract Tuberculosis remains a serious human public health concern. The coevolution between its pathogen Mycobacterium tuberculosis and human host complicated the way to prevent and cure TB. Apoptosis plays subtle role in this interaction. The pathogen endeavors to manipulate the apoptosis via diverse effectors targeting key signaling nodes. In this paper, we summarized the effectors pathogen used to subvert the apoptosis, such as LpqH, ESAT-6/CFP-10, LAMs. The interplay between different forms of cell deaths, such as apoptosis, autophagy, necrosis, is also discussed with a focus on the modes of action of effectors, and implications for better TB control.
Source: Apoptosis - Category: Molecular Biology Source Type: research

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Scientists prepare to examine sewage in attempt to try to find the source of a Covid-19 infection that killed Nathan TurnerPassengers on the ill-fated Ruby Princess cruise ship have been sent another warning from the New South Wales health department, warning that they could have been exposed to tuberculosis.The Ruby Princess voyage that arrived in Sydney on 19 March is responsible for about 10% of all coronavirus infections in Australia, and the bungled management of the outbreak has sparked two separate inquires.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Health Australia news Science Queensland Source Type: news
In conclusion, we report a COPD prevalence of 6.22% in HIV-infected individuals in rural Uganda. Pulmonary tuberculosis remains the strongest predictor of COPD risk and reduced lung function in well-controlled HIV. PMID: 32462945 [PubMed - as supplied by publisher]
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
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Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
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Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
Authors: Román-González A, Toro JP, Arias LF Abstract La insuficiencia suprarrenal primaria es un defecto en la producción de glucocorticoides, mineralocorticoides y andrógenos sexuales. Los pacientes afectados por esta condición se caracterizan por concentraciones bajas de cortisol y deficiencia de aldosterona con hiponatremia e hiperpotasemia concomitantes. La etiología más común es el desarrollo de anticuerpos contra la enzima 21 hidroxilasa. Otra causa importante de la insuficiencia suprarrenal primaria son las enfermedades infecciosas, en especial en los ...
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
This study sought to investigate the expression and diagnostic value of serum miR-145 in TB patients and explore the biological function of miR-145 using macrophages. Serum expression levels of miR-145 were estimated by quantitative real-time PCR. A receiver operating characteristic curve was plotted to evaluate the diagnostic accuracy of miR-145. This study further focused on the effects of miR-145 on cell viability and inflammation in macrophages upon Mtb infection, and explored the potential target gene of miR-145. Serum expression levels of miR-145 were decreased in TB patients, and the upregulated inflammatory cytokin...
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
Conditions:   Volatile Organic Compounds;   Radiography Interventions:   Device: electronic nose device;   Device: dig chest Xray with automated readings Sponsors:   Radboud University;   European Union;   ISPUP;   VHIR;   University Medical Center Groningen;   Laboratorio central de salud publica, Paraguay;   Instituto Nacional de Enfermedades Respiratorias y del Ambiente Juan Max Boetner;   National TB program Paraguay;   IICS Paragua...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Publication date: Available online 28 May 2020Source: Neurología (English Edition)Author(s): J. Romero-Imbroda, T. Sagrario-Fustero, C. Del Canto-Pérez, M. Requena-Pou
Source: Neurologia - Category: Neurology Source Type: research
Traveling man: the Goodwill Ambassador shares a joke with two residents of a leprosarium in Krantau, Uzbekistan during a visit in 2013.By External SourceMay 29 2020 (IPS-Partners)   Warm greetings from Sasakawa Health Foundation in Tokyo. The 100th Issue of the WHO Goodwill Ambassador’s Newsletter has been published. Read special interviews with the Goodwill Ambassador and the UN Special Rapporteur on leprosy, and check out the Timeline of all that has happened since the first issue. My Journey Continues I started this newsletter in April 2003 to share information about the fight against leprosy. This marks th...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Health Source Type: news
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