Similarities in the neuropathy phenotype of cancer survivors who received different classes of chemotherapy drugs

With the advent of platinum and taxane compounds, survival rates for some of the most common cancers have improved substantially. For both of these drug classes, the dose limiting toxicity is chemotherapy-induced peripheral neuropathy (CIPN), that occurs in 30% to 70% of cancer survivors.12, 33 CIPN is characterized by symptoms of pain, numbness, and paresthesia in the hands and feet that spread proximally in a “stocking-glove” distribution.8, 12, 35 CIPN is associated with a variety of common symptoms (e.g., sleep disturbance) and has negative effects on survivors’ quality of life (QOL).

Source: The Journal of Pain - May 6, 2022 Category: Materials Science Authors: Christine Miaskowski, Jon D. Levine, Steven M. Paul, Bruce Cooper, Gary Abrams, Kimberly Topp, Steven Cheung, Jennifer Henderson-Sabes, Yvette P. Conley, Karin Snowberg, Emely Alfaro, Marisa Quinn, Kord M. Kober Tags: Original Reports Source Type: research