Effects of statins on specialized pro-resolving mediators: An additional pathway leading to resolution of inflammation
Statins are a class of cholesterol-lowering drugs that inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. Anti-inflammatory and antioxidant properties, as well as improvement of endothelial function and plaque stabilization have also been proposed as parts of the pleiotropic effects of statins. Specialized pro-resolving mediators (SPMs) are endogenous lipid-derived molecules originating from ω-6 and ω-3 polyunsaturated fatty acids, such as arachidonic, docosahexaenoic and eicosapentaenoic acid that trigger and modulate the resolution of inflammation.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Shabnam Radbakhsh, Niki Katsiki, Raul D. Santos, Dimitri P. Mikhailidis, Christos S. Mantzoros, Amirhossein Sahebkar Source Type: research