Canine nasal neuroendocrine carcinoma: case report with a brief review of the literature

Abstract A mass of approximately 5 × 5 × 5 cm was located on the bridge of the nose, nasal septum, turbinates, and soft and hard palates of a 1-year-old male terrier dog. The skin over the mass was alopecic and ulcerated. Histopathologically, the tissue sections consisted of sheets of neoplastic cells separated by narrow bands of fibrovascular stroma. The neoplastic cells were round to polyhedral with moderate, eosinophilic cytoplasm, and large clear nuclei. Mitotic figures were frequently observed. Immunohistochemically, the neoplastic cells were diffusely positive for neuron-specific enolase, but no detectable cellular staining was evident for S-100 protein. Regarding the histopathological and immunohistochemical features of the tissue sections, neuroendocrine carcinoma was concluded in this case.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Abdul Wahab Jatoi, Ick Soo Kim, Hiroshi Ogasawara, Qing-Qing NiAbstractAlthough silver based nanofibers possess excellent bactericidal and bacteriostatic characteristics. However, excess release/contact with silver may induce harmful side-effects including carcinoma, argyria, argyrosis and allergies. Similarly, silver depletion may limit prolonged antibacterial activities as well. Thus present research proposes electrospun CA/ZnO/AgNPs composite nanofibers for biologically safer and sustained antibacterial applications. The Zn...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
This study aims to evaluate whether genetic variants in autophagy-related genes (ATGs) affect the development of HCC.Materials and methodsWe conducted a case-control study with 986 HCC cases and 1000 healthy controls to analyze 14 functional variants of five ATGs (ATG3, ATG5, ATG10, ATG12 and ATG16L1) among a Chinese population.Key findingsWe found ATG5 rs17067724 (G vs A: OR = 0.80; 95% CI = 0.65–0.98; P = 0.031), ATG10 rs1864183 (G vs A: OR = 1.29; 95% CI = 1.07–1.57; P = 0.009), ATG10 rs10514231 (C vs T: OR = 1.41; 95% CI = 1.15–1.73; P = 0.001), ATG12 rs26537 (C vs ...
Source: Life Sciences - Category: Biology Source Type: research
In this study, we tried to provide a mechanistic basis of apoptosis induced by TQ. Skin squamous carcinoma A431 cells were treated with TQ to monitor the apoptosis induced by TQ. Western blot analysis was performed to detect expression of apoptotic or anti-apoptotic proteins. Cell viability and apoptosis were measured by using the MTT test and FACS analysis, respectively. The induction of intracellular reactive oxygen species (ROS) by TQ was evaluated by 2′,7′-dichlorofluorescein diacetate staining. In vivo xenograft study was followed to confirm the antiproliferative effect of TQ. Treatment of A431 cells w...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: Available online 17 August 2019Source: Inorganic Chemistry CommunicationsAuthor(s): Li-Gang Zhu, Zhen-Feng Wang, Yue Gao, Qi-Pin Qin, Xiao-Ling Huang, Ming-Xiong Tan, Chu-Jie Zeng, Bi-Qun ZouAbstractTwo new quinolone ruthenium(II)-arene complexes, i.e., [Ru(cym)(DClQ)] (Ru1) and [Ru(cym)(ClQ)] (Ru2), with 5,7-dichloro-8-hydroxyquinoline (H-DClQ), 5-chloro-8-hydroxyquinoline (H-ClQ) and [(η6-p-cymene)RuI2]2 (cym), were first designed. The cytotoxic activity of two new quinolone Ru(II)-arene complexes Ru1 and Ru2 has been evaluated in T-24 bladder carcinoma, Hep-G2 hepatoma, BEL-7404 hepatocellular carc...
Source: Inorganic Chemistry Communications - Category: Chemistry Source Type: research
ConclusionsThe efficacy of adding bavituximab to sorafenib for the treatment of advanced HCC was inconclusive; however, the combination regimen did not exacerbate toxicities associated with single-agent sorafenib.ClinicalTrials.gov identifierNCT01264705.
Source: Targeted Oncology - Category: Cancer & Oncology Source Type: research
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Source: Current Treatment Options in Oncology - Category: Cancer & Oncology Source Type: research
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