DNA Methylation Levels in Hypothalamic-pituitary-adrenal Axis Genes Predict Chronic Pain Outcomes Following Trauma Exposure

Chronic posttraumatic musculoskeletal pain (CPTP) is a common outcome of traumatic stress exposure. Biological factors that predict risk for and mediate the development of CPTP are poorly understood. Current evidence indicates that dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis plays a substantial role in the development of CPTP. However, little is known about the molecular mechanisms that drive the association between HPA axis genes and CPTP, such as epigenetic regulatory mechanisms.

Source: The Journal of Pain - May 1, 2022 Category: Materials Science Authors: Erica Marie Branham, Ishani H. Deliwala, Matthew C. Mauck, Ying Zhao, Aaron Lee, Anthony Zannas, Lauren A. McKibben, Alex B. Spencer, Bruce A. Cairns, Megan Lechner, Teresa Danza, Michael C. Kurz, Marc-Anthony Velilla, Phyllis L. Hendry, Claire Pearson, E Tags: 2 Source Type: research