Early life incision induces an epigenetic modification in macrophages to drive neonatal nociceptive priming
Muscle injury evokes multiple biological responses including immune cell activation. Among these, macrophages are key players that regulate inflammation and nociception. They are also “trained” through pattern recognition and epigenetic modifications to facilitate future activity. Neonatal mechanisms of nociception are unique from that of adults but are less well studied. Basic and clinical studies agree that neonatal injury “primes” the individual, predisposing them to w orse outcomes following subsequent injury.
Source: The Journal of Pain - Category: Materials Science Authors: Adam Dourson, Anna M. Warshak, Megan C. Hofmann, Michael P. Jankowski Tags: 4 Source Type: research