Single-Cell Analysis of Dorsal Root Ganglia Reveals Metalloproteinase Signaling in Satellite Glial Cells and Pain

Somatosensory stimuli such as touch, temperature and pain are transduced in the periphery and transmitted to the central nervous system by primary sensory neurons, which cell bodies reside in sensory ganglia such as dorsal root ganglia (DRGs). Although DRG are complex tissues with neuronal and non-neuronal cells, diversity of non-neuronal cells and their function in homeostasis and pain are still unclear. Satellite glial cells (SGCs) are among the most abundant non-neuronal cells in DRGs and tightly envelop neurons providing metabolic and trophic support, buffering extracellular ions and neurotransmitters, and enabling neuromodulation.
Source: The Journal of Pain - Category: Materials Science Authors: Tags: 13 Source Type: research