Vitamin D counteracts fibrogenic TGF-{beta} signalling in human hepatic stellate cells both receptor-dependently and independently

Conclusions
VD may be an antifibrotic treatment option early in the onset of fibrosis in specific genotypes for VDR. Known polymorphisms of the VDR may influence the response to VD treatment.

Source: Gut - April 1, 2015 Category: Gastroenterology Authors: Beilfuss, A., Sowa, J.-P., Sydor, S., Beste, M., Bechmann, L. P., Schlattjan, M., Syn, W.-K., Wedemeyer, I., Mathe, Z., Jochum, C., Gerken, G., Gieseler, R. K., Canbay, A. Tags: Cirrhosis, Nonalcoholic steatosis Hepatology Source Type: research