Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells

Conclusions
H. pylori increase proliferation in a strain-specific manner in a novel gastroid system. H. pylori also alter expression and localisation of claudin-7 in gastroids and human epithelial cells, which is mediated by β-catenin and snail activation. These data provide new insights into molecular interactions with carcinogenic potential that occur between H. pylori and epithelial cells within the gastric niche.

Source: Gut - April 1, 2015 Category: Gastroenterology Authors: Wroblewski, L. E., Piazuelo, M. B., Chaturvedi, R., Schumacher, M., Aihara, E., Feng, R., Noto, J. M., Delgado, A., Israel, D. A., Zavros, Y., Montrose, M. H., Shroyer, N., Correa, P., Wilson, K. T., Peek, R. M. Tags: Editor's choice, Pancreatic cancer Helicobacter pylori Source Type: research