Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development

Conclusions KLF5/GATA4/GATA6 may promote GC development by engaging in mutual crosstalk, collaborating to maintain a pro-oncogenic transcriptional regulatory network in GC cells.

http://gut.bmj.com/cgi/content/short/64/5/707?rss=1

Source: Gut - April 1, 2015 Category: Gastroenterology Authors: Chia, N.-Y., Deng, N., Das, K., Huang, D., Hu, L., Zhu, Y., Lim, K. H., Lee, M.-H., Wu, J., Sam, X. X., Tan, G. S., Wan, W. K., Yu, W., Gan, A., Tan, A. L. K., Tay, S.-T., Soo, K. C., Wong, W. K., Dominguez, L. T. M., Ng, H.-H., Rozen, S., Goh, L.-K., Teh Tags: Pancreatic cancer Stomach Source Type: research