Association between early respiratory viral infections and structural lung disease in infants with cystic fibrosis

Infants with cystic fibrosis (CF) can develop trapped air and bronchiectasis early in life, even before 6 months of age, and in the absence of detectable CF respiratory pathogens [1]. Viral infections are associated with progressive clinical deterioration and significant morbidity in people with CF [2 –5]. However, there is insufficient information regarding the role of respiratory viruses in the pathogenesis of early CF lung disease. Viruses may alter the airway environment to permit bacterial colonization and interfere with bacterial clearance from the lungs [6–10].

Source: Journal of Cystic Fibrosis - May 3, 2022 Category: Respiratory Medicine Authors: Don B. Sanders, Ashley R. Deschamp, Joseph E. Hatch, James E. Slaven, Netsanet Gebregziabher, Mariette Kemner-van de Corput, Harm A.W.M. Tiddens, Tim Rosenow, Gregory A. Storch, Graham L. Hall, Stephen M. Stick, Sarath Ranganathan, Thomas W. Ferkol, Steph Source Type: research