Drosophila and experimental neurology in the post-genomic era.
Drosophila and experimental neurology in the post-genomic era. Exp Neurol. 2015 Mar 24; Authors: Shulman JM Abstract For decades, the fruit fly, Drosophila melanogaster, has been among the premiere genetic model systems for probing fundamental neurobiology, including elucidation of mechanisms responsible for human neurologic disorders. Flies continue to offer virtually unparalleled versatility and speed for genetic manipulation, strong genomic conservation, and a nervous system that recapitulates a range of cellular and network properties relevant to human disease. I focus here on four critical challenges emerging from recent advances in our understanding of the genomic basis of human neurologic disorders where innovative experimental strategies are urgently needed: (1) pinpointing causal genes from associated genomic loci; (2) confirming the functional impact of allelic variants; (3) elucidating nervous system roles for novel or poorly studied genes; and (4) probing network interactions within implicated regulatory pathways. Drosophila genetic approaches are ideally suited to address each of these potential translational roadblocks, and will therefore contribute to mechanistic insights and potential breakthrough therapies for complex genetic disorders in the coming years. Strategic collaboration between neurologists, human geneticists, and the Drosophila research community holds great promise to accelerate progress in the post-genomic era. PMID: 25...
Conclusion: Based on these results NDDS is considered to be an applicable instrument for identifying personality pathology in patients with depressive symptoms, by recognizing the specific pattern. This is thought to be important for adequate treatment planning. PMID: 31517547 [PubMed - as supplied by publisher]
The conversations -- all with college students between 18 and 21 -- give anecdotal looks into how the nicotine-addicted are dealing with what officials have called a public health crisis.
A 10-year-old girl is fighting for her life after she contracted a brain-eating amoeba after swimming in the Brazos River and Lake Whitney in Bosque County near Waco, Texas.
Don't do it. Please don't do it.
WHEN celebrated artist Alison Lapper began making plans for her wedding, her dream was for her son Parys to give her away.
[And we've reached the 50th Anniversary of Revista Argentina de Microbiología]. Rev Argent Microbiol. 2019 Jul - Sep;51(3):189-190 Authors: Di Conza JA, Predari SC PMID: 31514958 [PubMed - in process]
I am a big fan of Prue Leith, 79, pictured, and have no doubt her knowledge of souffles is unsurpassed, I'm not sure if the same can be said of her medical experience, writes EVE SIMMONS.
PMID: 31514692 [PubMed - in process]
As a child born in 2018, my little girl has a one in three chance of living to 100. In contrast, as someone born in 1917, Pamela would have been considered lucky to live past 60.
CONCLUSIONS Our results demonstrated a regulation loop among MATAL1, miR-194, and YAP1, which dynamically regulates the progression of AP, providing a new therapeutic target for treatment of this disease. PMID: 31518341 [PubMed - in process]