Pancreas Transplantation for Type 2 Diabetes Mellitus: Who and Why?

Abstract In the past, type 2 diabetes mellitus (T2DM) was a contraindication for simultaneous pancreas-kidney transplantation (SPKT) even though it was generally accepted to be an effective treatment option for selected patients with type 1 DM (T1DM) and advanced chronic kidney disease. However, because there may be tremendous overlap in the clinical presentations of T1DM versus T2DM, the presence of detectable C-peptide is no longer considered reliable in determining DM “type.” Experiences with SPKT in uremic patients with detectable pretransplant C-peptide levels with a type 2 diabetes phenotype (older age of onset of DM and older age at transplant, shorter duration of insulin-requiring DM, higher body weight/BMI, higher proportion of African-Americans) have demonstrated outcomes equivalent to those with T1DM although clearly a more robust selection bias exists for patients with presumed T2DM. The success of SPKT in this setting provides evidence that the pathophysiology of T2DM is heterogeneous and not related exclusively to insulin resistance. The purpose of this review is to summarize evidence that appropriately selected uremic patients with T2DM may benefit from SPKT, with a focus on recipient selection in order to optimize outcomes.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

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ConclusionPresumed higher anti-leukemic activity of RIC versus NMA conditioning did not translate into better outcomes after alloHSCT, but better remission status prior to conditioning did. Effective pathway inhibitor-based salvage therapies combined with NMA conditioning might thus represent the most attractive contemporary approach for alloHSCT for patients with CLL.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
This study analyzed PCT and CRP levels of 214 pediatric patients with a median age of 8.5  years (0.4–17.8 years) undergoing allogeneic HSCT with respect to major TRAE.Results26 patients (12.1%) did not experience TRAE (control group), and 188 (87.9%) experienced median 2 (range 1 –4) TRAE. Median CRP and PCT were highly and significantly increased during sepsis/SIRS and bacteremia (17.24 mg/dl | 6.30 ng/ml;p 
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: Our study is designed to highlight how fibrofatty changes are minimal using CMRI in the pediatric population and how this can be a valuable tool to provide an additional method of diagnosis. PMID: 31625461 [PubMed - as supplied by publisher]
Source: Fetal and Pediatric Pathology - Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research
Authors: Sedano R, Castro L, Venegas M, Miranda J, Hurtado C, Poniachik J, Brahm J Abstract Hepatitis B virus (HBV) related acute liver failure (ALF) is uncommon in our region, and there is limited HBV literature regarding the optimal management of these cases. In this article, we report two clinical cases of young men who have sex with men (MSM), both developed severe acute hepatitis caused by HBV, progressed to ALF and afterward required liver transplantation. Antiviral post-transplant treatment included entecavir without Hepatitis B Immunoglobulin (HBIG), and immunosuppression therapy with steroids, tacrolimus, ...
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
Publication date: Available online 19 October 2019Source: The Annals of Thoracic SurgeryAuthor(s): Leona T. Yarboro
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 15 October 2019Source: Food Research InternationalAuthor(s): Mohammed Bule, Shekoufeh Nikfar, Mohsen Amini, Mohammad AbdollahiAbstractThymoquinone (2-isopropyl-5-methylbenzo-1, 4-quinone) (TQ) is a quinone derivative with a yellow crystalline appearance, abundantly found in black cumin, Nigella sativa L. TQ has diverse pharmacological properties. The aim of this systematic review on the antidiabetic effects of TQ is to evaluate the currently available evidence and conduct meta-analysis. A literature search of articles published until 25 January 2019 was done on PubMed, EMBASE, Web of Scie...
Source: Food Research International - Category: Food Science Source Type: research
Publication date: Available online 9 October 2019Source: Food Research InternationalAuthor(s): Dave Jaydeep Pinakin, Vikas Kumar, Sheenam Suri, Rakesh Sharma, Manisha KaushalAbstractA numerous types of tree flowers are present in nature and few of them such as Rhdodendron, Bauhinia, Mahua, Gulmohar, Palash, Sesbania, Woodfordia, Simbal, etc. are being utilized traditionally as food and medicine by the localities of India. These flowers are rich in phytochemical (flavonoids, anthocyanins, phenolic acids, carotenoids, tannins, saponins) and possessing numerous health benefits (antioxidant activity, anti-inflammation, anti-ca...
Source: Food Research International - Category: Food Science Source Type: research
This study evaluates the effects of a chemically characterized polyphenolic extract of H. sabdariffa (HSE) in an experimental model of diet-induced obesity (DIO) in mice. HSE was administered daily by oral gave for 42 days. HSE reduced weight increase in high fat diet (HFD)-fed mice, and improved glucose tolerance, insulin sensitivity and normalized LDL/HDL cholesterol ratio. It also enhanced the inflammatory state in the liver, reducing the expression of different adipokines and proinflammatory mediators, and reinforced gut integrity by increasing the expression of mucins and proteins involved in the maintenance of mucosa...
Source: Food Research International - Category: Food Science Source Type: research
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Source: Molecular and Biochemical Parasitology - Category: Parasitology Source Type: research
Publication date: Available online 18 October 2019Source: Journal of Molecular BiologyAuthor(s): Leticia P. Roma, Jean-Christophe JonasAbstractInsulin-secreting pancreatic β-cells play a critical role in blood glucose homeostasis and the development of type 2 diabetes (T2D) in the context of insulin resistance. Based on data obtained at the whole cell level using poorly specific chemical probes, reactive oxygen species (ROS) like superoxide and hydrogen peroxide have been proposed to contribute to the stimulation of insulin secretion by nutrients (positive role) and to the alterations of cell survival and secretory fu...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
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