New Tool for EDC Research: In Vivo Assay Screens for Estrogenic Effects

Carrie Arnold is a freelance science writer living in Virginia. Her work has appeared in Scientific American, Discover, New Scientist, and more. About This Article open Citation: Arnold C. 2015. New tool for EDC research: in vivo assay screens for estrogenic effects. Environ Health Perspect 123:A95; http://dx.doi.org/10.1289/ehp.123-A95 News Topics: Chemical Testing, Endocrine Disruptors, Alternative Test Models Published: 1 April 2015 PDF Version (519 KB) Related EHP Article Development of Phenotypic and Transcriptional Biomarkers to Evaluate Relative Activity of Potentially Estrogenic Chemicals in Ovariectomized Mice Sylvia C. Hewitt, Wipawee Winuthayanon, Brianna Pockette, Robnet T. Kerns, Julie F. Foley, Norris Flagler, Elizabeth Ney, Apichart Suksamrarn, Pawinee Piyachaturawat, Pierre R. Bushel, and Kenneth S. Korach With more than 84,000 chemicals currently listed in the Toxic Substances Control Act inventory1 and many of them lacking significant toxicologic data,2 it’s no easy task to pick out potential endocrine-disrupting compounds. In this issue of EHP, researchers describe a new in vivo screen they believe will improve efforts to identify high-priority chemicals for further study.3 High-throughput in vitro assays used by programs such as the U.S. Environmental Protection Agency’s ToxCast™ help with preliminary screening, but they can’t identify how a compound may affect the body, says first author Sylvia Hewitt of the National Institute ...
Source: EHP Research - Category: Environmental Health Authors: Tags: Featured News Science Selection Alternative Test Models April 2015 Chemical Testing Endocrine Disruptors Source Type: research