High-dose magnesium sulfate in the treatment of aconite poisoning.

This article reports the case of a 62-year-old male patient who ingested the roots of Monkshood (Aconitum napellus) and white hellebore (Veratrum album) dissolved in alcohol with a suicidal intention and suffered cardiotoxic and neurotoxic symptoms. After contacting the Poison Information Centre ventricular arrhythmia was treated with high-dose magnesium sulphate as the only antiarrhythmic agent and subsequently a stable sinus rhythm could be established after approximately 3 h. Aconitum napellus is considered the most poisonous plant in Europe and it is found in gardens, the Alps and the Highlands. Poisoning is mainly caused by the alkaloid aconite that leads to persistent opening and activation of voltage-dependent sodium channels resulting in severe cardiac and neurological toxicity. As no specific antidote is known so far, poisoning is associated with a high mortality. The therapy with high-dose magnesium sulphate is based on in vitro and animal experiments as well as limited clinical case reports. PMID: 25812545 [PubMed - as supplied by publisher]
Source: Der Anaesthesist - Category: Anesthesiology Authors: Tags: Anaesthesist Source Type: research

Related Links:

A growing body of research has examined self-reported measures of social network alcohol use, such as the Important People Instrument (IPI), among college students. However, it remains unknown whether IPI judgments of friends' alcohol use are accurate. We ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Childhood Maltreatment and Non-Suicidal Self-Injury - the Impact of Emotion Regulation Non-suicidal self-injury (NSSI) is a common phenomenon in adolescence. Furthermore, it is often associated with maltreatment during childhood. One factor determin...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Obesity is associated with a significant disease burden, but whether recognising as opposed to failing to recognise personal overweight is beneficial or detrimental to mental health is unclear. Here we examine the associations between perceived overweight ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND: Pediatric medical conditions have the potential to result in challenging psychological symptoms (eg, anxiety, depression, and posttraumatic stress symptoms [PTSS]) and impaired health-related quality of life in youth. Thus, effective and access...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
AIM: To examine the relationships of physical activity (PA) and sedentary behaviour (SB) with suicidal thoughts and behaviour among adolescents in low- and middle-income countries (LMICs). METHODS: Global School-based Student Health Survey data fro...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
The popular Netflix show 13 Reasons Why graphically depicts the story of a teenager who commits suicide. As media and fictional portrayals of suicide are known to influence suicidal behaviors, professional organizations expressed concern that the show woul...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Binge drinking adolescents often present to the emergency department with an alcohol intoxication. Known clinical signs of alcohol intoxications are impaired consciousness and vomiting, occasionally complicated by pulmonary aspiration. Emergency physicians...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Shame and Compassion: Potential Mechanisms Behind Bullying and Depressive Symptoms With a prevalence of 11 % depression is a relevant topic for child- and adolescent-psychiatry. Different factors play a role in genesis and maintenance of depressive ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
This study was conducted to assess abuse and depression in elderly individuals. The universe of this descriptive and cross-sectional study consisted of individuals over the age of 65  years who were attending in a university at Turkish Republic of Northern...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
[Abstract unavailable] Language: en...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
More News: Alcoholism | Anesthesia | Anesthesiology | Arrhythmia | Cardiology | Depression | Heart | Magnesium | Neurology | Poisoning | Suicide | Toxicology | Ventricular Arrhythmia