Targeting AML at the intersection of epigenetics and signaling

Sci Signal. 2022 Apr 19;15(730):eabo0059. doi: 10.1126/scisignal.abo0059. Epub 2022 Apr 19.ABSTRACTMutations in multiple cancers may synergize to alter the cellular epigenetic and transcriptional state and corrupt key signaling pathways. In this issue of Science Signaling, Pedicona et al. illustrate how the two processes intersect to regulate cellular differentiation in acute myeloid leukemia (AML) and show how inhibition of epigenetic regulators promotes sensitivity to kinase inhibitors.PMID:35439022 | DOI:10.1126/scisignal.abo0059

Source: Science Signaling - April 19, 2022 Category: Biomedical Science Authors: Nisha Narayan Brian J P Huntly Source Type: research