P2X7 receptor ‐mediated release of microglial prostanoids and miRNAs correlates with reversal of neuropathic hypersensitivity in rats
ConclusionsWe have identified a pain-relevant P2X7 receptor-regulated mechanism in neuropathic rats, which could hold promise as a translatable biomarker and by association enhance the clinical progression of P2X7 receptor antagonists in neuropathic pain.SignificanceSub-optimal translation of preclinical molecules has hindered the clinical development of novel mechanism of action analgesics. We have undertaken a comprehensive in vitro analysis of migroglial signalling mechanisms recruited upon P2X7 receptor activation, a number of which were shown to be modulated by a selective P2X7 receptor antagonist in a well characterized animal model of neuropathic pain. Subject to further confirmation in other neuropathic models, this opens up the possibility to investigate their clinical utility as potential pain biomarkers in patients.
Source: European Journal of Pain - Category: Anesthesiology Authors: Roland Staal,
Tanzilya Khayrullina,
Rie Christensen,
Sara Hestehave,
Hua Zhou,
Manuel Cajina,
Megan E. Nattini,
Adarsh Gandhi,
Shaun M. Fallon,
Megan Schmidt,
Stevin H. Zorn,
Robbin M. Brodbeck,
Gamini Chandrasena,
M ärta Segerdahl,
Nathali Tags: ORIGINAL ARTICLE Source Type: research
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