Challenges and Potential for Ovarian Preservation with SERMs.

Challenges and Potential for Ovarian Preservation with SERMs.
Biol Reprod. 2015 Mar 25;
Authors: Ting AY, Petroff BK
Abstract
Tamoxifen (TAM) is a selective estrogen receptor modulator (SERM) with tissue-specific effects on estrogen signaling used predominantly for treatment and chemoprevention of breast cancers. Recent studies have shown that TAM prevents infertility and decreases follicular loss from common cancer chemotherapy and radiation therapy in preclinical models. Here we review current and novel uses of SERMs and advantages and challenges for translation of TAM for human fertility preservation.
PMID: 25810474 [PubMed - as supplied by publisher]

Source: Biology of Reproduction - March 25, 2015 Category: Reproduction Medicine Authors: Ting AY, Petroff BK Tags: Biol Reprod Source Type: research