(459) Evaluation of liquid spray technology for sublingual drug delivery

Sublingual drug administration may be appropriate in multiple disease states, such as in patients who require rapid onset of effect (eg, transmucosal immediate-release fentanyl for breakthrough cancer pain [fentanyl sublingual spray]) or have conditions that negatively impact oral medication administration (eg, dysphagia, xerostomia), or when hepatic first-pass metabolism avoidance is desired. It is important for a sublingual spray device to accurately deliver microliter quantities of appropriate droplet size (eg, to prevent lung deposition) and have a simple, easy-to-use, durable mechanical design (eg, no springs).

Source: The Journal of Pain - March 27, 2015 Category: Materials Science Authors: K. Vangara, C. Cognata Smith, N. Parikh, A. Chavan, V. Goskonda Source Type: research