Chromoscopy and Adenoma Detection in Lynch SyndromeChromoscopy and Adenoma Detection in Lynch Syndrome
Is chromocolonoscopy more effective than standard colonoscopy at detecting adenomas in patients with Lynch syndrome? The American Journal of Gastroenterology
DEAR MAYO CLINIC: I am considering undergoing genetic testing to see if I have the gene mutation that causes Lynch syndrome. Because of my family history, I already have regular colonoscopies even though I?m only 41. What would knowing I have the mutation change as far as how I?m monitored for colon cancer? ANSWER: Knowing [...]
ConclusionPatients with LS have an increased risk of MC, especially CRCs. With a median time period of 24 months between colonoscopy and metachronous CRC, the interval between surveillance colonoscopies following primary CRC should not exceed 18 months, especially in patients with MSH2 mutation.
AbstractPurposeLynch syndrome (LS) is associated with a high risk of colorectal cancer (CRC). The aim of this study was to assess the cumulative risk for the development of colorectal adenomas or carcinomas in a LS CRC surveillance program and to audit the quality of the endoscopic procedures.MethodsWe evaluated 147 asymptomatic LS mutation carriers, without previous CRC, in a surveillance program with colonoscopy every 12 –18 months, between 2005 and 2016. Data was obtained by retrospective review of colonoscopy reports and hospital clinical files. The main outcome was assessed using Kaplan–Meier curves. ...
Conditions: Lynch Syndrome; Colonoscopy Intervention: Diagnostic Test: Colonoscopy Sponsors: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); FUJIFILM Europe GmbH Not yet recruiting
Conclusion: A proinflammatory potential of the diet does not seem to be significantly associated with CRT risk in persons with LS.
ConclusionsThe hypothesis that the high incidence of CRC inpath_MLH1 carriers was caused by a higher incidence in the Finnish series was not valid. We discuss whether the results were influenced by methodological shortcomings in our study or whether the assumption that a shorter interval between colonoscopies leads to a lower CRC incidence may be wrong. This second possibility is intriguing, because it suggests the dogma that CRC inpath_MLH1 carriers develops from polyps that can be detected at colonoscopy and removed to prevent CRC may be erroneous. In view of the excellent 10-year overall survival in the Finnish and non-...
Conclusion: A proinflammatory potential of the diet does not seem to be significantly associated with CRT risk in persons with LS. PMID: 28931533 [PubMed - as supplied by publisher]
Background Individuals with hereditary non-polyposis colorectal cancer (HNPCC) have a high risk of colorectal cancer (CRC). The benefits of colonic surveillance in Lynch syndrome and Amsterdam-positive (familial CRC type X familial colorectal cancer type X (FCCTX)) families are clear; only the interval between colonoscopies is debated. The potential benefits for families not fulfilling the Amsterdam criteria are uncertain. The aim of this study was to compare the outcome of colonic surveillance in different hereditary subgroups and to evaluate the surveillance programmes. Methods A prospective, observational study on the ...