MARK-AGE Biomarkers of Ageing

Publication date: Available online 24 March 2015 Source:Mechanisms of Ageing and Development Author(s): Alexander Bürkle , María Moreno-Villanueva , Jürgen Bernhard , María Blasco , Gerben Zondag , Jan Hoeijmakers , Olivier Toussaint , Beatrix Grubeck-Loebenstein , Eugenio Mocchegiani , Sebastiano Collino , Sthatis Gonos , Ewa Sikora , Daniela Gradinaru , Martijn Dolle , Michel Salmon , Peter Kristensen , Helen Griffiths , Claude Libert , Tilman Grune , Nicolle Breusing , Andreas Simm , Claudio Franceschi , Miriam Capri , Duncan Talbot , Paola Caiafa , Bertrand Friguet , Eline Slagboom , Antti Hervonnen , Mikko Hurme , Richard Aspinall Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently performed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3300 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.

Source: Mechanisms of Ageing and Development - March 24, 2015 Category: Geriatrics Source Type: research