Obesogens beyond Vertebrates: Lipid Perturbation by Tributyltin in the Crustacean Daphnia magna

Conclusions: TBT disrupted the dynamics of neutral lipids impairing the transfer of triacylglycerols to eggs and hence promoting their accumulation in adult individuals. TBT disruptive effects translated into a lower fitness for offspring and adults. Co-regulation of gene transcripts suggests that TBT activates the ecdysone, JH and RXR receptor signaling pathways, presumably through the already proposed interaction with RXR. This is the first clear evidence of obesogenic effects in a non-vertebrate species. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Jordão R, Casas J, Fabrias G, Campos B, Piña B, Lemos MF, Soares AM, Tauler R, Barata C. Obesogens beyond Vertebrates: Lipid Perturbation by Tributyltin in the Crustacean Daphnia magna. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1409163. Received: 2 September 2014 Accepted: 19 March 2015 Advance Publication: 24 March 2015 EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the comple...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Article Source Type: research