“ Why multiple myeloma returns ” …

That’s the title of an interesting Science Daily article that I came across this morning (and that blog reader Ana also told me about in a comment I read soon afterward, thank you!). Here’s the link: https://www.sciencedaily.com/releases/2022/03/220301131117.htm?utm_source=feedburner&utm_medium=email In a nutshell, a group of researchers at the Charité – Universitätsmedizin Berlin discovered that the culprit to the HUGE problem of drug resistance (non-genetic drug resistance, in particular) in myeloma is the increased production of a protein, the CDK6 protein, which not only activates cell proliferation but also, interestingly, binds with one of myeloma’s best buddies, Cyclin D1 (about which I’ve written quite a lot…do a Search of the blog if you are interested in the topic). Okay, so we now have a culprit: CDK6. Guess what? Well, by now this should not come as a surprise: curcumin inhibits CDK6, just as it inhibits Cyclin D1. Bazinga! Will the curcumin-CDK6 connection ever be studied in the conventional myeloma world? I doubt it, oh very much so, for what I believe are obvious reasons. No, what will happen is that a conventional drug, probably with lots of side effects, will be studied, tested, and put on the market. It’s frustrating…so many missed opportunities to help us myeloma folks (as well as other folks with different types of cancer). So many missed opportunities… To be honest, I think that’s probably...
Source: Margaret's Corner - Category: Cancer & Oncology Authors: Tags: Blogroll CDK6 protein in myeloma Source Type: blogs