Urinary monocyte chemoattractant protein-1 and hepcidin and early diabetic nephropathy lesions in type 1 diabetes mellitus

Conclusions Elevated urinary MCP-1 concentration measured before clinical findings of DN in women with T1D was associated with changes in kidney interstitial volume, suggesting that inflammatory processes may be involved in the pathogenesis of early interstitial changes in DN.
Source: Nephrology Dialysis Transplantation - Category: Urology & Nephrology Authors: Tags: Chronic Kidney Disease Source Type: research

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ConclusionThus our results showed that higher IL-37 was associated with increased insulin sensitive in elderly type 2 DM patients through suppressing the gut microbiota dysbiosis.
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Oral semaglutide, the investigational first oral GLP-1 receptor agonist, could expand currently suboptimal treatment options for patients with type 2 diabetes and moderate renal impairment.Medscape Medical News
Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Diabetes & Endocrinology News Source Type: news
Publication date: Available online 24 June 2019Source: Reactive and Functional PolymersAuthor(s): Tawfik A. Khattab, Moustafa M.G. Fouda, Meram S. Abdelrahman, Sarah I. Othman, May Bin-Jumah, Maha Abdulla Alqaraawi, Haifa Al Fassam, Ahmed A. AllamAbstractOne of the major consequences resulting from chronic kidney failure is a considerable increase in the level of metabolism waste products in blood, including urea that is naturally released by kidney. Herein, we report a novel practical colorimetric test gauze strip for an efficient recognition of urea in serum was developed. The prepared testing gauze strip was based on a ...
Source: Reactive and Functional Polymers - Category: Chemistry Source Type: research
Publication date: Available online 22 June 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Rocio Thea, Diego Onna, Mark P. Kreuzer, Mariana HamerAbstractOne of the main confirmatory metabolites of diabetes mellitus is known as glycosylated hemoglobin (HbA1c), a hemoglobin modified with cis-diol sugars. This work presents an optical detection of this metabolite via the preparation and characterization of glass surfaces coated with gold nanoparticles (AuNPs) and subsequently modified with boronic acid to enhance specificity. Through the localized surface plasmon resonance intrinsic to the AuNPs an absorbance enhancem...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
DR JASON WELLEN (St Louis, MO): Dr Cannon and colleagues have presented a retrospective analysis of United Network for Organ Sharing (UNOS) data comparing the outcomes of kidney transplantation, after a simultaneous liver kidney transplantation (SLK), compared with a matched cohort of kidney transplants. They used UNOS data between 2003 and 2012 in order to incorporate the changes to the Model for End-Stage Liver Disease (MELD) allocation. Their manuscript sought to illustrate the potential lost life years of kidney allografts that are being transplanted as SLKs.
Source: Journal of the American College of Surgeons - Category: Surgery Tags: Western surgical association article Source Type: research
Cardiovascular outcomes trials show beneficial effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on both cardiovascular and renal outcomes, sparking renewed interest in cardiorenal syndrome.Medscape Diabetes &Endocrinology
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Diabetes & Endocrinology Commentary Source Type: news
Condition:   Transplanted Organ Rejection Intervention:   Biological: FCR001 Sponsor:   Talaris Therapeutics Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Crohn’s Disease in Clinical Remission Is Marked by Systemic Oxidative Stress Arno R. Bourgonje1, Julius Z. H. von Martels1, Marian L. C. Bulthuis2, Marco van Londen3, Klaas Nico Faber1, Gerard Dijkstra1† and Harry van Goor2*† 1Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands 2Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands 3Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Gro...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
AbstractPurpose of ReviewThe choice of optimum transplant in a patient with type 1 diabetes mellitus (T1DM) and chronic kidney disease stage V (CKD V) is not clear. The purpose of this review was to investigate this in more detail —in particular the choice between a simultaneous pancreas-kidney transplantation (SPKT) and living donor kidney transplantation (LDKT), including recent evidence, to aid clinicians and their patients in making an informed choice in their care.Recent FindingsAnalyses of large databases have recently shown SPKT to have better survival rates than a LDKT in the long-term, despite an early incre...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
Abstract In the past, type 2 diabetes mellitus (T2DM) was a contraindication for simultaneous pancreas-kidney transplantation (SPKT) even though it was generally accepted to be an effective treatment option for selected patients with type 1 DM (T1DM) and advanced chronic kidney disease. However, because there may be tremendous overlap in the clinical presentations of T1DM versus T2DM, the presence of detectable C-peptide is no longer considered reliable in determining DM “type.” Experiences with SPKT in uremic patients with detectable pretransplant C-peptide levels with a type 2 diabetes phenotype (old...
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research
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