Alone or combined with serotoninergic agents, the progestins of the gonane family may represent a therapeutic alternative for Ondine's curse syndrome

Rev Mal Respir. 2022 Feb 11:S0761-8425(22)00029-8. doi: 10.1016/j.rmr.2022.01.008. Online ahead of print.ABSTRACTCentral hypoventilation syndromes such as Ondine's curse are rare neurorespiratory diseases associated with dysregulation of the vegetative (or autonomous) nervous system. They are characterized by a defect in the automatic control of ventilation, with a severe reduction or even the absence of CO2/H+ chemosensitivity. As no effective pharmacotherapy currently exists, lifelong mechanical ventilation is the only available treatment for patients suffering from these syndromes. In this context, clinical observation and studies in animal models suggest that gonane progestins, alone or in combination with serotonergic agents, could constitute a therapeutic alternative.PMID:35165014 | DOI:10.1016/j.rmr.2022.01.008
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Authors: Source Type: research