Herbal extracts that induce type I interferons through Toll-like receptor 4 signaling

CONCLUSIONS: INT induced type I IFN mRNA and proteins in BMDMs and other cell types. This induction was mediated by TLR4, which transduces signals using the TRIF/MyD88 pathway. The high-MW component of INT contained type I IFN inducing activity. The supernatants from INT-treated cells displayed antiviral activity and protected cells from EMCV infection. These findings indicate that INT is a novel natural IFN inducer that strengthens host's innate immunity.PMID:35173566 | PMC:PMC8809074 | DOI:10.29219/fnr.v66.5524

Source: Food and Nutrition Research - February 17, 2022 Category: Nutrition Authors: Misa Nakasuji-Togi Sumihito Togi Keita Saeki Yasuhiko Kojima Keiko Ozato Source Type: research