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VIDEO: Once-yearly skin cancer screening might not be enough after organ transplants

SAN FRANCISCO – Older white men are most at risk to die from skin cancer after organ transplants, especially if they’ve had a heart or lung transplant, according to a review of more than a half million U.S. organ transplants from 1987-2013. It’s long been known that skin cancer is far more likely...
Source: Skin and Allergy News - Category: Dermatology Tags: ONCR Video FPN News FPN Dermatology IMN News IMN Dermatology SAN Clinical News SAN News SAN SCN: Melanoma Source Type: news

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Immune checkpoints are accessory molecules that either promote or inhibit T cell activation. Two inhibitory molecules, cytotoxic T cell antigen 4 (CTLA-4) and programmed death 1 (PD-1), got high attention, as inhibition of CTLA-4 or PD-1 signaling provides the first immune therapy that significantly improves the survival of patients with metastatic solid cancers. Inhibition of CTLA-4 or PD-1 was first studied in and approved for patients with metastatic melanoma. Blocking immune checkpoints is also efficient in non-small-cell lung cancer, renal cell cancers, hypermutated gastro-intestinal cancers and others.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Abstract Myeloid-derived suppressor cells (MDSCs) are capable of suppressing the immune response. 5-Fluorouracil (5-FU) compared to other chemotherapy drugs have shown considerable decreases in the number of MDSCs without visible effects on T, B and natural killer cells, as well as dendritic cells (DCs). DC-based vaccines considered to be appropriate candidates for cancer immunotherapy. However, due to the presence of various factors like MDSCs in tumor microenvironment, DC vaccine cannot effectively perform its function. The purpose of this study was to evaluate the effect of low doses of 5-FU on the efficacy of ...
Source: Iranian Journal of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Iran J Allergy Asthma Immunol Source Type: research
AbstractOrgan transplant recipients (OTRs) are a population at high risk for cutaneous adverse events. Their early recognition and appropriate treatment is an important component of the clinical management of OTRs and should be optimally dealt with by dermatologists working in the context of a transplant dermatology clinic. Skin examination should be a standard procedure before performing organ transplantation to assess conditions which may be difficult to manage after the transplant procedure has been performed or which may represent a contraindication to transplantation, e.g., malignant melanoma. It also offers an opport...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Publication date: October 2017 Source:Chinese Journal of Natural Medicines, Volume 15, Issue 10 Author(s): Jin-Jun HOU, Yao SHEN, Zhou YANG, Lin FANG, Lu-Ying CAI, Shuai YAO, Hua-Li LONG, Wan-Ying WU, De-An GUO Abstract Euphorbia kansui is a commonly used traditional Chinese medicine for the treatment of edema, pleural effusion, and asthma, etc. According to the previous researches, terpenoids in E. kansui possess various biological activities, e.g., anti-virus, anti-allergy, antitumor effects. In this work, twenty five terpenoids were isolated from E. kansui, including thirteen ingenane- and eight jatrophane-type diterpe...
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research
Elevated serum tryptase values may be found in several conditions, including mastocytosis, myeloproliferative neoplasms, hypereosinophilic disorders, and myelodysplastic syndromes. Increased density of tissue mast cells is correlated with poor prognosis in lung adenocarcinoma as well as melanoma, gastric carcinoma, and breast cancer. While an elevated tryptase has been proposed as a biomarker in several hematologic malignancies including chronic myeloid leukemia, an elevated tryptase has not been previously reported in association with lung adenocarcinoma.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
ConclusionDesign limitations of the study include that all findings of skin cancer were based on clinical examination only and must therefore be considered tentative diagnoses. Furthermore, owing to the cross‐sectional study design, causal pathways cannot be proven. However, analyses of data from such a large and general population‐based cohort afford valuable insights into the relationship between atopic diseases and skin cancer. They provide the grounds for prospective cohort studies to evaluate and dissect the underlying mechanism.
Source: Journal of the European Academy of Dermatology and Venereology - Category: Dermatology Authors: Tags: Original Article Source Type: research
ConclusionDesign limitations of the study include that all findings of skin cancer were based on clinical examination only and must therefore be considered tentative diagnoses. Furthermore, owing to the cross‐sectional study design, causal pathways cannot be proven. However, analyses of data from such a large and general population‐based cohort afford valuable insights into the relationship of atopic diseases and skin cancer. They provide the grounds for prospective cohort studies to evaluate and dissect the underlying mechanism.This article is protected by copyright. All rights reserved.
Source: Journal of the European Academy of Dermatology and Venereology - Category: Dermatology Authors: Tags: Original Article Source Type: research
Abstract A protective effect of allergy for cancer has been suggested, but the results are somewhat conflicting, and the mechanism remains elusive. Interleukin-4 (IL-4) signaling has been identified as a potentially important pathway in the development of allergies and the suppression of cancer development. To evaluate the allergy responses in IL-4-mediated tumor development, we compared the growth of B16F10 melanoma cells in 4% phthalic anhydride (PA)-treated IL-4/Luc/CNS-1 transgenic mice (IL-4 mice) and acetone-olive oil (AOO)-treated IL-4 mice as a control for 3 weeks. Much higher allergic responses and natura...
Source: Neoplasia - Category: Cancer & Oncology Authors: Tags: Neoplasia Source Type: research
Conclusions Molecular assessment of MAGE-A family members could be considered to improve the prognostic evaluation and to provide a new potential therapeutic strategy for patients with LAC.
Source: Journal of Clinical Pathology - Category: Pathology Authors: Tags: Immunology (including allergy), Lung cancer (oncology), Lung cancer (respiratory medicine) Original article Source Type: research
About 5% of sunlight is ultraviolet (UV). UV causes gene mutations in skin cells, and is the main cause of all forms of skin cancer. Sun protection is crucial for people at high risk of malignant melanoma: those with fair skin, who are moley or have a family history of melanoma. Sun protection is required in patients at risk of squamous and basal cell skin cancers, and is vital in patients with sunlight allergies. There is no agreement about how much sun protection is advisable for healthy adults at low risk of skin cancer.
Source: Medicine - Category: Internal Medicine Authors: Tags: Photoprotection of the skin Source Type: research
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