RNA-stabilizing proteins as molecular targets in cardiovascular pathologies
The stability of mRNA has emerged as a key step in the regulation of eukaryotic gene expression and function. RNA stabilizing proteins (RSPs) contain several RNA recognition motifs, and selectively bind to adenylate-uridylate-rich elements in the 3′ untranslated region of several mRNAs leading to altered processing, stability, and translation. These post-transcriptional gene regulations play a critical role in cellular homeostasis; therefore act as molecular switch between ‘normal cell’ and ‘disease state.’ Many mRNA binding proteins have been discovered to date, which either stabilize (HuR/HuA, HuB, HuC, HuD) or destabilize (AUF1, tristetraprolin, KSRP) the target transcripts.
Source: Trends in Cardiovascular Medicine - Category: Cardiology Authors: Sahana Suresh Babu, Darukeshwara Joladarashi, Prince Jeyabal, Rajarajan A. Thandavarayan, Prasanna Krishnamurthy Source Type: research