A diagnostic index based on quantitative susceptibility mapping and voxel-based morphometry may improve early diagnosis of Alzheimer ’s disease

ConclusionsIn this preliminary study, the proposed index based on QSM and VBM improved the diagnostic performance between MCI and NC groups compared with the VBM-based index.Key Points•We developed a novel diagnostic index for Alzheimer ’s disease based on quantitative susceptibility mapping (QSM) and voxel-based morphometry (VBM).•QSM and VBM images can be acquired simultaneously in a single sequence with little increasing scan time.•In this preliminary study, the proposed diagnostic index improved the discriminative performance between mild cognitive impairment and normal control groups compared with the conventional VBM-based index.
Source: European Radiology - Category: Radiology Source Type: research