Association Between Prediabetes and Osteoarthritis: A Meta-Analysis
Horm Metab Res 2022; 54: 104-112 DOI: 10.1055/a-1730-5251Some studies have suggested that diabetes may be a risk factor for
osteoarthritis. However, whether prediabetes is also associated with
osteoarthritis has not been comprehensively examined. We performed a
meta-analysis to evaluate the relationship between prediabetes and
osteoarthritis. This meta-analysis included relevant observational studies from
Medline, Embase, and Web of Science databases. A random-effect model after
incorporation of the intra-study heterogeneity was selected to pool the results.
Ten datasets from six observational studies were included, which involved 41 226
general adults and 10 785 (26.2%) of them were prediabetic. Pooled
results showed that prediabetes was not independently associated with
osteoarthritis [risk ratio (RR): 1.07, 95% confidence interval (CI):
1.00 to 1.14, p=0.06, I2=0%]. Sensitivity
limited to studies with adjustment of age and body mass index showed consistent
result (RR: 1.06, 95% CI: 0.99 to 1.14, p=0.09,
I2=0%). Results of subgroup analyses showed that
prediabetes was not associated with osteoarthritis in cross-sectional or cohort
studies, in studies including Asian or non-Asian population, or in studies with
different quality scores (p for subgroup difference>0.10). Besides,
prediabetes was no...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Li, Xi Zhou, Yong Liu, Jianxiu Tags: Endocrine Care Source Type: research
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