Construction and evaluation of dual-effect cord blood natural killer cells expressing highaffinity PD-1 and chimeric antigen CD19 receptor

CONCLUSION: We obtained a novel dual-effect CBNKC co-expressing HAPD1 and CAR. The cells show strong cytotoxicity against the target tumor cells both in vitro and in vivo, which sheds light on a new strategy of immunotherapy against tumor cells.PMID:35012922 | PMC:PMC8752428 | DOI:10.12122/j.issn.1673-4254.2021.12.18

Source: Journal of Southern Medical University - January 11, 2022 Category: Universities & Medical Training Authors: H Zhong Q Zou H Liu X Wang S DU H Liang Z Wu J Ye Q Zou Source Type: research