Human Leukocyte Antigen Association Study Reveals DRB1*04:02 Effects Additional to DRB1*07:01 in Anti-LGI1 Encephalitis

Discussion
In addition to the established primary DRB1*07:01 association in anti-LGI1 encephalitis, we observe a secondary effect of DRB1*04:02 with lower age at onset. Our study provides evidence for secondary effects within HLA locus that correlate with clinical phenotypes in anti-LGI1 encephalitis.

Source: Neurology Neuroimmunology and Neuroinflammation - February 3, 2022 Category: Neurology Authors: Peris Sempere, V., Muniz-Castrillo, S., Ambati, A., Binks, S., Pinto, A.-L., Rogemond, V., Pittock, S. J., Dubey, D., Geschwind, M. D., Gelfand, J. M., Dilwali, S., Lee, S.-T., Knight, J., Elliott, K. S., Irani, S., Honnorat, J., Mignot, E. Tags: Article Source Type: research