Household transmissibility of avian influenza A (H7N9) virus, China, February to May 2013 and October 2013 to March 2014.

Household transmissibility of avian influenza A (H7N9) virus, China, February to May 2013 and October 2013 to March 2014. Euro Surveill. 2015;20(10) Authors: Yang Y, Zhang Y, Fang L, Halloran ME, Ma M, Liang S, Kenah E, Britton T, Chen E, Hu J, Tang F, Cao W, Feng Z, Longini IM PMID: 25788253 [PubMed - in process]
Source: Euro Surveill - Category: Infectious Diseases Authors: Tags: Euro Surveill Source Type: research

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Publication date: Available online 27 February 2020Source: Antiviral ResearchAuthor(s): Hongyu Qiu, Hanne Andersen, E. Bart Tarbet, F. Salih Muhammad, Trevor Carnelley, Russell Pronyk, Douglas Barker, Shantha Kodihalli
Source: Antiviral Therapy - Category: Virology Source Type: research
In this study, we collected 693 nasal swab samples and 800 blood samples from stray dogs in animal shelters to survey canine influenza epidemiology and characterize the evolution of CIV H3N2 in Shanghai. We tested samples for canine influenza antibodies and canine influenza RNA in January –May, 2019, and the results showed that the positive rate was 17.62% by ELISA, 15.75% by microneutralization (MN) assay, and 18.51% by real time RT-PCR, respectively. We also performed phylogenetic and genomic analysis on six H3N2 CIV isolates. The H3N2 viruses which prevailed in Shanghai originat ed from Beijing and Jiangsu isolate...
Source: Virus Genes - Category: Genetics & Stem Cells Source Type: research
(BfR Federal Institute for Risk Assessment) In the Federal State of Brandenburg, a case of highly pathogenic avian influenza (often referred to as bird flu) was found in a wild goose, caused by a virus of the H5N8 subtype. According to the current state of scientific knowledge, it is unlikely that the pathogen can be transmitted to humans via food.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Contributors : Qingtao Liu ; Yin Li ; Jing YangSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusWe analyze the differentially expressed genes (DEGs) at the transcriptome level in chicken DCs infected with H9N2 influenza virus compared to mock infection by high-throughput RNA-sequencing technology, and found that H9N2 influenza virus infection induced a strong innate immune response in chicken DCs, but impaired the antigen-processing and –presenting capacity of this cell,
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Gallus gallus Source Type: research
Publication date: Available online 22 February 2020Source: Pharmacology &TherapeuticsAuthor(s): Kimiyasu Shiraki, Tohru DaikokuAbstractFavipiravir has been developed as an anti-influenza drug and licensed as an anti-influenza drug in Japan. Additionally, favipiravir is being stockpiled for 2 million people as a countermeasure for novel influenza strains. This drug functions as a chain terminator at the site of incorporation of the viral RNA and reduces the viral load. Favipiravir cures all mice in a lethal influenza infection model, while oseltamivir fails to cure the animals. Thus, favipiravir contributes to curing an...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: A historical anchor for vaccination rates and ILI is provided in a large cohort of college students following the 2009 H1N1 influenza pandemic. Influenza immunization locations were determined, as was self-reported obstacles to receiving vaccinations. These are important results for public health leaders seeking to increase vaccination rates during future influenza seasons. PMID: 32074350 [PubMed - in process]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Current influenza vaccines only confer protection against homologous viruses. We synthesized pulmonary surfactant (PS)–biomimetic liposomes encapsulating 2',3'-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP), an agonist of the interferon gene inducer STING (stimulator of interferon genes). The adjuvant (PS-GAMP) vigorously augmented influenza vaccine–induced humoral and CD8+ T cell immune responses in mice by simulating the early phase of viral infection without concomitant excess inflammation. Two days after intranasal immunization with PS-GAMP–adjuvanted H1N1 vaccine, strong cross-p...
Source: ScienceNOW - Category: Science Authors: Tags: Immunology, Microbiology, Online Only r-articles Source Type: news
The emergence of human infection with avian influenza A(H7N9) virus was reported in Wenshan City, southwestern China in 2017. The study describes the epidemiological and virological features of the outbreak an...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
Publication date: Available online 17 February 2020Source: Clinical Epidemiology and Global HealthAuthor(s): Krishna Prasad Acharya, Niran Adhikari, Muhammad TariqAbstractThe agro-climatic conditions, socio-economic situation, poor sanitation, low hygiene and health standards in Nepal are major contributing factors to the emergence of scrub typhus in Nepal. These outbreaks, along with poor diagnostic facilities, can lead to severe economic losses in a resource-limited country like Nepal. Diseases like avian influenza, leptospirosis, brucellosis, tuberculosis and rabies, that cause heavy socio-economic burden, have received...
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
In this study, we show that OA-10, a newly synthesized triterpene out of 11 oleanane-type derivatives, exhibited significant antiviral activity against four different subtypes of IAV (H1N1, H5N1, H9N2 and H3N2) replications in A549 cell cultures with EC50 ranging from 6.7 to 19.6 μM and a negligible cytotoxicity (CC50 > 640 μM). It inhibited acid-induced hemolysis in a dose-dependent manner, with an IC50 of 26 µM, and had a weak inhibition on the adsorption of H5 HA to chicken erythrocytes at higher concentrations (≥40 µM). Surface plasmon resonance (SPR) analysis showed that...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
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