Chronic edible dosing of Δ9-tetrahydrocannabinol (THC) in non-human primates reduces systemic platelet activity and function

This study investigates the effects of chronic THC administration on platelet function using a non-human primate (NHP) model. Our results show that female and male NHPs consuming a daily THC edible had reduced platelet adhesion, aggregation and granule secretion in response to select platelet agonists. Furthermore, a change in bioactive lipids (oxylipins) was observed in the female cohort after THC administration. Indicating that chronic THC edible administration desensitized platelet activity and function in response to GPVI- and G-protein coupled receptor-based activation by interfering with primary and secondary feedback signaling pathways. These observations may have important clinical implications for patients who use medical marijuana and for providers caring for these patients.PMID:35080922 | DOI:10.1152/ajpcell.00373.2021
Source: American Journal of Physiology. Cell Physiology - Category: Cytology Authors: Source Type: research