Fluid Balance and Ventilator-Associated Events Among Patients Admitted to ICUs in China: A Nested Case-Control Study*
This study investigated the dose-response relationship between fluid balance and ventilator-associated events.
DESIGN:
Nested case-control study.
SETTING:
The study was based on a well-established, research-oriented registry of healthcare-associated infections at ICUs of West China Hospital system (Chengdu, China).
PATIENTS:
A total of 1,528 ventilator-associated event cases with 3,038 matched controls, who consistently underwent mechanical ventilation for at least 4 days from April 1, 2015, to December 31, 2018, were included.
INTERVENTIONS:
None.
MEASUREMENTS AND MAIN RESULTS:
We calculated cumulative fluid balance within 4 days prior to ventilator-associated event occurrence. A weighted Cox proportional hazards model with restricted cubic splines was used to evaluate the dose-response relationship. A nonlinear relationship between fluid balance and all three tiers of ventilator-associated events, patients with fluid balance between –1 and 0 L had the lowest risk (p
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Clinical Investigations Source Type: research