Effects of Lipid Overload on Heart in Metabolic Diseases

Horm Metab Res 2021; 53: 771-778 DOI: 10.1055/a-1693-8356Metabolic diseases are often associated with lipid and glucose metabolism
abnormalities, which increase the risk of cardiovascular disease. Diabetic
cardiomyopathy (DCM) is an important development of metabolic diseases and a
major cause of death. Lipids are the main fuel for energy metabolism in the
heart. The increase of circulating lipids affects the uptake and utilization of
fatty acids and glucose in the heart, and also affects mitochondrial function.
In this paper, the mechanism of lipid overload in metabolic diseases leading to
cardiac energy metabolism disorder is discussed. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text

Source: Hormone and Metabolic Research - December 10, 2021 Category: Endocrinology Authors: Yan, An Xie, Guinan Ding, Xinya Wang, Yi Guo, Liping Tags: Review Source Type: research