Effectiveness of sacral neuromodulation in patients with Parkinson's disease

CONCLUSION: NMS improves urinary symptoms in the patients with Parkinson's disease in 32% of cases. It fluctuates over time and loses its effectiveness in the long term.LEVEL OF EVIDENCE: 3.PMID:35027284 | DOI:10.1016/j.purol.2021.04.007
Source: Progres en Urologie - Category: Urology & Nephrology Authors: Source Type: research

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Condition:   Attention-Deficit Hyperactivity Disorder (ADHD) Interventions:   Drug: PDC-1421 Capsule;   Drug: Placebo Sponsor:   BioLite, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Multiple Sclerosis, Relapsing-Remitting Interventions:   Drug: IMU-838 tablets;   Drug: Placebo matching IMU-838 tablets Sponsor:   Immunic AG Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Excessive sympathetic outflow following trauma can lead to cardiac dysfunction, inflammation, coagulopathy, and poor outcomes. We previously reported that buprenorphine analgesia decreased survival after hemorrhagic trauma. Our aim is to examine the underlying mechanisms of mortality in a non-compressible hemorrhage rat model resuscitated with saline or adenosine, lidocaine, magnesium (ALM). Anesthetized adult male Sprague-Dawley rats were randomly assigned to Saline control group or ALM therapy group (both n = 10). Hemorrhage was induced by 50% liver resection. After 15 min, 0.7 mL/kg 3% NaCl ± ALM intr...
Source: Shock - Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research
In recent years, researchers have investigated retrotransposon activity in the context of aging. Retrotransposons, a class of transposable element, are sequences in the genome capable of replication, perhaps archeological debris from the ancient interactions of cells and viruses, co-opted by evolution. Transposable elements are largely suppressed in youth, but the suppression mechanisms become less effective in later life, one of countless cellular mechanisms that runs awry for reasons that are far from fully understood. It is a challenge to connect specific changes in gene expression to specific underlying causes of aging...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
CNS Neurosci Ther. 2022 Jan 21. doi: 10.1111/cns.13806. Online ahead of print.ABSTRACTSurvival analysis of reaching EDSS ≥4.0 based on RoAD score ≥4 (dashed line) and
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Source Type: research
Cerebellum. 2022 Jan 21. doi: 10.1007/s12311-021-01357-1. Online ahead of print.ABSTRACTIn recent years, a growing body of literature has investigated the use of non-invasive brain stimulation (NIBS) techniques to influence cerebellar activity and the effects of cerebellar stimulation on other brain regions through its multiple complex projections. From the early 1990s, with the discovery of the so-called cerebellar inhibition (CBI), several studies have focused their attention on the use of cerebellar NIBS as treatment for different motor disorders. Cerebellar ataxias (CAs) represent the prototypical clinical manifestatio...
Source: Cerebellum - Category: Neuroscience Authors: Source Type: research
CONCLUSION: NMS improves urinary symptoms in the patients with Parkinson's disease in 32% of cases. It fluctuates over time and loses its effectiveness in the long term.LEVEL OF EVIDENCE: 3.PMID:35027284 | DOI:10.1016/j.purol.2021.04.007
Source: Progres en Urologie - Category: Urology & Nephrology Authors: Source Type: research
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