Decrease in MAP3Ks expression enhances the cell death caused by hyperthermia

CONCLUSIONS: Hyperthermia decreased the levels of MAP3K TAK1, RAF1 and MEKK2, without reduction of the downstream components in the MAP3K-MAP2K-MAPK cascade, by a calpain-dependent degradation pathway or transcriptional regulation. TAK1, RAF1 and/or MEKK2 play crucial roles in cell proliferation and clonogenicity and are potential molecular targets for hyperthermia.PMID:35042442 | DOI:10.1080/02656736.2021.2024281
Source: International Journal of Hyperthermia - Category: Internal Medicine Authors: Source Type: research