Temperature Management and Health-Related Quality of Life in Children 3 Years After Cardiac Arrest

OBJECTIVES: Therapeutic hypothermia minimizes neuronal injury in animal models of hypoxic-ischemic encephalopathy with greater effect when used sooner after the insult. Clinical trials generally showed limited benefit but are difficult to perform in a timely manner. In this clinical study, we evaluated the association between the use of hypothermia (or not) and health-related quality of life among survivors of pediatric cardiac arrest as well as overall mortality. DESIGN: Single-center, retrospectively identified cohort with prospective assessment of health-related quality of life. SETTING: PICU of a pediatric hospital. PATIENTS: Children with either out-of-hospital or in-hospital cardiac arrest from January 2012 to December 2017. INTERVENTIONS: Patients were assigned into two groups: those who received therapeutic hypothermia at less than or equal to 35°C and those who did not receive therapeutic hypothermia but who had normothermia targeted (36–36.5°C). The primary outcome was health-related quality of life assessment and the secondary outcome was PICU mortality. MEASUREMENTS AND MAIN RESULTS: We studied 239 children, 112 (47%) in the therapeutic hypothermia group. The median (interquartile range) of lowest temperature reached in the 48 hours post cardiac arrest in the therapeutic hypothermia group was 33°C (32.6–33.6°C) compared with 35.4°C (34.7–36.2°C) in the no therapeutic hypothermia group...
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Feature Articles Source Type: research

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The body of a child found Saturday in an alley in Gary, Indiana, showed evidence of hypothermia and "partially frozen" internal organs, according to the coroner. #alley #coroner
Source: Reuters: Health - Category: Consumer Health News Source Type: news
CONCLUSION: FET is a versatile, established surgical technique that allows for several applications in different pathologies and innovative adaptations. How, when, and why FET is extended needs to be reported in greater detail, with specific consideration given to the interaction of FET and endovascular devices in sizing, integrity, and possible complications.PMID:35015899
Source: Surgical Technology International - Category: Surgery Authors: Source Type: research
Journal of Perinatology, Published online: 11 January 2022; doi:10.1038/s41372-021-01307-zComment on ‘value of cranial ultrasound at initiation of therapeutic hypothermia for neonatal encephalopathy’
Source: Journal of Perinatology - Category: Perinatology & Neonatology Authors: Source Type: research
AbstractThe ability to induce a hypothermia resembling that of natural torpor would be greatly beneficial in medical and non-medical fields. At present, two procedures based on central nervous pharmacological manipulation have been shown to be effective in bringing core body temperature well below 30  °C in the rat, a non-hibernator: the first, based on the inhibition of a key relay in the central thermoregulatory pathway, the other, based on the activation of central adenosine A1 receptors. Although the role of mitochondria in the activation and maintenance of torpor has been extensively stud ied, no data are ava...
Source: Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology - Category: Physiology Source Type: research
For evaluation of the contribution of the antioxidant system of mitochondria into the dynamics of changes in the prooxidant status, the content and activity of some of its components were studied under conditions of moderate hypothermia of varying duration. It was found that short-term hypothermia significantly increased superoxide dismutase activity and decreased the levels of low-molecular-weight antioxidants. Increasing the duration of hypothermia to 1 h led to suppression of activities of superoxide dismutase, glutathione reductase, and glutathione peroxidase and a decrease in glutathione content. Further prolongation ...
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research
Spinal Cord, Published online: 10 January 2022; doi:10.1038/s41393-021-00747-wA prospective multi-center study comparing the complication profile of modest systemic hypothermia versus normothermia for acute cervical spinal cord injury
Source: Spinal Cord - Category: Research Authors: Source Type: research
ConclusionsEmergency surgery for AAAD using a standard conservative approach showed an improved outcome in octogenarians. The majority of patients could return home with an acceptable living.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionThe AL risk nomogram could not be validated using the international LekCheck study database. In the future, intraoperative predictive factors for AL, as identified in this study, should also be included in AL risk predictors.
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
Pediatric patients, especially neonates and infants, undergoing cardiac surgery are at particularly high risk for developing surgical bleeding. After separation from cardiopulmonary bypass (CPB), excessive bleeding in children frequently requires the administration of large volumes of blood products to achieve hemostasis. In the operating room, this period of bleeding and transfusion of blood products is associated with hemodynamic instability, prolonged operation time, hypothermia, and the need for escalating inotropic support.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Editorial Source Type: research
Spinal tumor surgery usually involved long operation time, large area of soft tissue resection and long wound, and was prone to hypothermia during the operation. Therefore, actively promoting insulation and op...
Source: BMC Surgery - Category: Surgery Authors: Tags: Research article Source Type: research
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